Early Use of Polymyxin B Hemoperfusion in Abdominal Septic Shock
نویسندگان
چکیده
منابع مشابه
Polymyxin B Hemoperfusion for Septic Shock -- Ready for Primetime? Early Use of Polymyxin B Hemoperfusion in Abdominal Septic Shock: The EUPHAS Randomized Controlled Trial
Background: Treatments for severe sepsis are limited, and its morbidity and mortality, especially from Gramnegative organisms, continues to be significant. Gram-negative organisms release endotoxin, which initiates inflammatory and coagulation cascades, resulting in end-organ dysfunction in patients. Polymyxin B hemoperfusion filters bind endotoxin. Objective: To assess the efficacy of polymyxi...
متن کاملEarly use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial.
CONTEXT Polymyxin B fiber column is a medical device designed to reduce blood endotoxin levels in sepsis. Gram-negative-induced abdominal sepsis is likely associated with high circulating endotoxin. Reducing circulating endotoxin levels with polymyxin B hemoperfusion could potentially improve patient clinical outcomes. OBJECTIVE To determine whether polymyxin B hemoperfusion added to conventi...
متن کاملPolymyxin B-immobilized fiber column hemoperfusion therapy for septic shock.
Endotoxin, an outer membrane component of gram-negative bacteria, plays an important role in the pathogenesis of septic shock. Endotoxin adsorption therapy by polymyxin B-immobilized fiber column hemoperfusion (PMX) has been used for the treatment of septic shock patients in Japan since 1994. The covalent binding of polymyxin B onto the surface of the polystyrene-based carrier fiber in PMX inac...
متن کاملTime to initiation of treatment with polymyxin B cartridge hemoperfusion in septic shock patients.
BACKGROUND We investigated whether early initiation of hemoperfusion with a polymyxin B cartridge (PMX) after the diagnosis of septic shock could improve the clinical outcome. METHODS A prospective, open-labeled, multicenter cohort study was performed at intensive care units in Japan. 41 patients received PMX within 6 h after the diagnosis of septic shock (early group) and 51 patients were tr...
متن کامل[Hemoperfusion with polymyxin B in septic shock secondary to Klebsiella pneumoniae induced liver abscesses].
Los abscesos hepáticos (AH) son infrecuentes1, aumentando actualmente por el manejo enérgico de enfermedades hepato-biliares y pancreáticas2. Es una enfermedad emergente y potencialmente letal, que hasta hace poco presentaba una mortalidad superior al 31%2,3, y ahora su pronóstico ha mejorado gracias al desarrollo de técnicas de imagen, el uso de antibióticos más eficaces y el drenaje percutáne...
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ژورنال
عنوان ژورنال: JAMA
سال: 2009
ISSN: 0098-7484
DOI: 10.1001/jama.2009.856